Endocrine Abstracts

Introduction and aim: Type 1 diabetes mellitus (T1DM) presents as a challenge for both health care providers and patients looking to avoid chronic complications and early mortality. Clinical features of patients with long duration T1DM are still poorly studied and debated. The aim of our work was to describe the clinical features of subjects with long duration T1DM.Methods: Cross-sectional study of patients with T1DM with more than 40 years of evolution ...

Aim: Differential diagnosis (DD) of thyrotoxicosis is critical as the treatment of the three main causes of this condition (Graves’ disease [GD], Toxic Multinodular Goitre [TMG], and Thyroiditis [TS]) differs substantially. Recently published diagnostic algorithms investigating hyperthyroidism embrace the presence of thyrotropin receptor (TSH-R) antibodies (TRab) as the first and most cruicial diagnostic step. Although TRab measurement has important limitations (some can ...

Introduction: One of the main difficulties in the study of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) is their wide heterogeneity and variable outcome. Several potential influencing factors on patient survival have been recently identified. These factors could help predict patients’ prognosis.Objectives: Analysis of long-term survival of our GEP-NETs cohort according to the presence of metastatic disease, tumor grade, age, sex, tumor fu...

Introduction: Signalling lymphocytic activation molecule SLAMF1 (CD150) is a modulatory receptor expressed in most immune cells. Different data indicate that CD150 is involved in T cell cytokine production, NK cell and CD8 T cell mediated cytotoxicity, and T regulatory (Treg) cell activity. Patients with autoimmune thyroid disease (AITD) show defects in their immune-regulatory mechanisms. Herein we assessed the expression and function CD150 in lymphocytes subpopulations from p...

Introduction: Angiopoietins (ANG) -1 and 2, their receptor TIE2, and the vascular endothelial growth factor (VEGF) are involved in the process of angiogenesis. However, their role in the pathogenesis and development of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) is not completely understood. In a previous study of 42 patients with GEP-NET, we observed an elevation of these serum markers, especially in those with metastatic disease. The objective of this study was ...

Introduction: Decreased bone formation has been proposed as a mechanism involved in the higher risk of fractures in diabetic patients. Some clinical studies have found that sclerostin (SCL, a negative regulator of bone formation) is increased in diabetic patients. However, there is no information about the relationship between SCL and new onset diabetes after transplantation (NODAT). The aim of our study is to evaluate serum SCL levels in a cohort of patients with liver transp...

Introduction: The fine needle aspiration cytology (FNAC) of thyroid nodules is the procedure of choice in the diagnostic approach of nodular thyroid disease. Despite showing a sensitivity of 83% and a specificity of 92%, many of the results are non-diagnostic. One of the factors that can contribute to this number is the proper procedure of the smear.Objective: To compare the FNAC’s results in our team with and without the contribution of an expert C...

Introduction: Patients with autoimmune thyroid disease (AITD) exhibit aberrant immune-regulatory mechanisms. Galectins (Gal) are a family of glycan-binding proteins, which have been involved in immune regulation. However, the association of Gal with AITD remains unknown. In this study, we evaluated serum Gal-1 and Gal-9 in patients with AITD.Methods: Peripheral blood samples from 31 patients with Graves’ disease (GD) (14 with untreated hyperthyroidi...

Background: Data on sexual dysfunction (SD) in cirrhotic patients are limited. Our aim was to evaluate the sexual function of patients with end-stage liver disease and to compare it with the results after liver transplant (LT) and with that of a controlled group matched by age and gender.Methods: Changes in sexual functioning questionnaire were used to evaluate SD in cirrhotic patients awaiting LT and in the post-LT setting 1 year after transplant. Clini...

Introduction: Craniopharyngiomas are benign epitelial tumors located in the suprasellar region and they are associated to several comorbidities. Our aim is to describe hormonal deficiency and complications after surgery.Design: Descriptive study of patients that underwent surgery of craniopharyngioma. Data collected included hormonal levels, clinical data and mortality. Quantitative variables with normal distribution are shown as mean and standard deviat...